The European Cardiovascular Health data and AI Network - CHAIN is a three-year European collaboration for trustworthy AI in cardiovascular and related non-communicable disease care coordinated by the European Society of Cardiology and co-funded by the European Union’s EU4Health programme. It brings together 53 partners from 20 countries to help close the gap between promising AI solutions and their safe, effective and scalable use in cardiovascular care. CHAIN will connect a federated data ecosystem, AI evaluation and deployment services, regulatory support and six real-world use cases to generate practical evidence, tools and guidance for healthcare systems across Europe.

CHAIN MISSION: From connected data to AI that works in practice - CHAIN brings together data, AI and real-world implementation to accelerate safe and equitable adoption across European healthcare systems.

• Connected data - CHAIN will reduce the fragmentation that currently limits the reuse of cardiovascular health data by improving interoperability, harmonisation, metadata and data quality across participating organisations. In line with the European Health Data Space (EHDS), this will support consistent data authorised use through shared standards and governance approaches.
• Discoverable AI -CHAIN will make AI solutions easier to find, understand and assess by combining a searchable repository aligned with FAIR principles (Findable, Accessible, Interoperable, Reusable) with AI Passports and evaluation services.
• Real-world implementation - CHAIN will test selected AI solutions in six real-world use cases across different clinical settings and populations, generating evidence on performance, implementation barriers and transferability. This will help identify what is needed for trustworthy AI solutions to move from validation towards broader adoption in cardiovascular care.

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