Project Publications

Our current projects are generating exciting and cutting-edge knowledge!

Explore the 147 publications so far below

AlternativesToGd

Alternatives to Gadolinium

Title Authors Journal Link
Laser-Synthesis of NV-Centers-Enriched Nanodiamonds: Effect of Different Nitrogen Sources L Basso et al. Micromachines Read
Increasing the sensitivity of hyperpolarized [15N2]urea detection by serial transfer of polarization to spin‐coupled protons F Kreis et al. Magnetic Resonance in Medicine Read
Hyperpolarized water through dissolution dynamic nuclear polarization with UV-generated radicals AC Pinon et al. Communications Chemistry Read

 

MEDIRAD

Implications of medical low dose radiation exposure

Title Authors Journal Link
Automatic Tube Current Modulation and Tube Voltage Selection in Pediatric Computed Tomography AE Papadakis et al. Investigative Radiology Read
Does deep inspiration breath-hold prolong life? Individual risk estimates of ischaemic heart disease after breast cancer radiotherapy C Simonetto et al. Radiotherapy and Oncology Read
Early Detection of Cardiovascular Changes After Radiotherapy for Breast Cancer: Protocol for a European Multicenter Prospective Cohort Study (MEDIRAD EARLY HEART Study) V Walker et al. JMIR Research Protocols Read
Implications of Medical Low Dose Radiation Exposure (MEDIRAD) E Cardis et al. European Congress of Radiology 2018 (EuroSafe Imaging poster exhibition) Read
Clinical Trials in Radiology MO Bernier et al. Insights into Imaging Read
Conference Program J Damilakis Medical Physics Read
"MEDIRAD - Implications of Medical Low Dose Radiation Exposure": A European-funded project aims to enhance the protection of patients and health professionals from exposure to low dose medical radiation A Palma et al. Physica Medica Read
Risk for cardiovascular events responds nonlinearly to carotid intima-media thickness in the KORA F4 study C Simonetto et al. Atherosclerosis Read
OpenDose: open access resources for nuclear medicine dosimetry M Chauvin et al. Journal of Nuclear Medicine Read
Radio-biologically motivated modeling of radiation risks of mortality from ischemic heart diseases in the Canadian fluoroscopy cohort study H Schöllnberger et al. Radiation and Environmental Biophysics Read
Standardised quantitative radioiodine SPECT/CT Imaging for multicentre dosimetry trials in molecular radiotherapy RA Gregory et al. Physics in Medicine & Biology Read
A multicentric IT platform for storage and sharing of imaging-based radiation dosimetric data J Spaltenstein et al. International Journal of Computer Assisted Radiology and Surgery Read
A Hybrid Reporting Platform for Extended RadLex Coding Combining Structured Reporting Templates and Natural Language Processing F Jungmann et al. Journal of Digital Imaging Read
When Stiffness Matters: Mechanosensing in Heart Development and Disease R Gaetani et al. Frontiers in Cell and Developmental Biology Read
Evaluation of an organ-based tube current modulation tool in pediatric CT examinations AE Papadakis et al. European Radiology Read
Longitudinal atherosclerotic changes after radio(chemo)therapy of hypopharyngeal carcinoma C Simonetto et al. Radiation Oncology Read
Compartmental Model for 223Ra-Dichloride in Patients With Metastatic Bone Disease From Castration-Resistant Prostate Cancer J Taprogge et al. International Journal of Radiation Oncology*Biology*Physics Read

 

SOLUS

Smart optical and ultrasound diagnostics of breast cancer

Title Authors Journal Link
Non-invasive optical estimate of tissue composition to differentiate malignant from benign breast lesions: A pilot study P Taroni et al. Scientific Reports Read
Chromophore decomposition in multispectral time-resolved diffuse optical tomography J Zouaoui et al. Biomedical Optics Express Read
Time-domain diffuse optical tomography using silicon photomultipliers: feasibility study L Di Sieno et al. Journal of Biomedical Optics Read
High throughput detection chain for time domain optical mammography E Ferocino et al. Biomedical Optics Express Read
Attractive new technologies for 7-wavelength time domain optical mammography E Ferocino et al. Diffuse Optical Spectroscopy and Imaging VI Read
Performance evaluation of time-domain multispectral diffuse optical tomography in the reflection geometry L Hervé et al. Diffuse Optical Spectroscopy and Imaging VI Read
Gating techniques for InGaAs/InP and silicon SPADs A Tosi et al. Single Photon Workshop 2017 Read
Novel Approaches to Photon Detection and Timing for 7-Wavelength Time Domain Optical Mammography E Ferocino et al. 19th Italian National Conference on Photonic Technologies (Fotonica 2017) Read
How Should the New Generation of Detectors for Diffuse Optics Be? A Systematic Simulation Study L Di Sieno et al. Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS) Read
Novel Technologies for Time-Domain Diffuse Optics: Miniaturized Wearable Devices and Bioresorbable Optical Fibers A Dalla Mora et al. Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS) Read
Advances in Single-Photon Detection and Timing for Time Domain Multi-Wavelength Optical Mammography E Ferocino et al. Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS) Read
Instrumental, optical and geometrical parameters affecting time-gated diffuse optical measurements: a systematic study A Behera et al. Biomedical Optics Express Read
Systematic study of the effect of ultrasound gel on the performances of time-domain diffuse optics and diffuse correlation spectroscopy L Di Sieno et al. Biomedical Optics Express Read
Multi Simulation Platform for Time Domain Diffuse Optical Tomography: An Application to a Compact Hand-Held Reflectance Probe E Ferocino et al. Applied Sciences Read
Multi-wavelength time domain diffuse optical tomography for breast cancer: initial results on silicone phantoms E Ferocino et al. Optical Tomography and Spectroscopy of Tissue XIII Read
Solid heterogeneous phantoms for multimodal ultrasound and diffuse optical imaging: an outcome of the SOLUS project for standardization L Di Sieno et al. Novel Biophotonics Techniques and Applications V Read
Effects of ultrasound impedance matching fluids on diffuse optical measurements L Di Sieno et al.Taroni, Antonio Pifferi, Alberto Dalla Mora Diffuse Optical Spectroscopy and Imaging VII Read
Spectral approach to time domain diffuse optical tomography for breast cancer: validation on meat phantoms E Ferocino et al. Diffuse Optical Spectroscopy and Imaging VII Read
Fitting a spectral model for component analysis in diffuse optical tomography G Di Sciacca et al. Diffuse Optical Spectroscopy and Imaging VII Read
Large area SiPM and high throughput timing electronics: toward new generation time-domain instruments A Behera et al. Diffuse Optical Spectroscopy and Imaging VII Read
A Tool for Quantitative and Systematic Simulation of Diffuse Optical Tomography with a Limited Number of Fixed Sources and Detectors E Ferocino et al. Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS) Read
Study of optimal measurement conditions for time-domain diffuse optics systems A Behera et al. Biophotonics: Photonic Solutions for Better Health Care VI Read

 

LUCA

Laser and Ultrasound Co-analyzer for Thyroid Nodules

Title Authors Journal Link
A Compact Two-Wavelength Time-Domain NIRS System Based on SiPM and Pulsed Diode Lasers M Buttafava et al. IEEE Photonics Journal Read
Time-resolved single-photon detection module based on silicon photomultiplier: A novel building block for time-correlated measurement systems E Martinenghi et al. Review of Scientific Instruments Read
Liquid phantoms for near-infrared and diffuse correlation spectroscopies with tunable optical and dynamic properties L Cortese et al. Biomedical Optics Express Read
Time-resolved near infrared light propagation using frequency domain superposition S Wojtkiewicz et al. Biomedical Optics Express Read
Broadband (550-1350 nm) diffuse optical characterization of thyroid chromophores S Konugolu Venkata Sekar et al. Scientific Reports Read
Eight-Wavelength, Dual Detection Channel Instrument for Near-Infrared Time-Resolved Diffuse Optical Spectroscopy M Renna et al. IEEE Journal of Selected Topics in Quantum Electronics Read
Broadband (600-1100 nm) Diffuse Optical Characterization of Thyroid Tissue Constituents and Application to in vivo Thyroid Studies S Konugolu Venkata Sekar et al. Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS) Read
Novel Technologies for Time-Domain Diffuse Optics: Miniaturized Wearable Devices and Bioresorbable Optical Fibers A Dalla Mora et al. Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS) Read
Systematic study of the effect of ultrasound gel on the performances of time-domain diffuse optics and diffuse correlation spectroscopy L Di Sieno et al. Biomedical Optics Express Read
In vivo time-gated diffuse correlation spectroscopy at quasi-null source-detector separation M Pagliazzi et al. Optics Letters Read
Multi-wavelength dual-detection channel system for time-resolved near-infrared spectroscopy M Renna et al. Proceedings Volume 10874, Optical Tomography and Spectroscopy of Tissue XIII; 1087408 (2019) Read
Self-calibrating time-resolved near infrared spectroscopy S Wojtkiewicz et al. Biomedical Optics Express Read

 

HYPMED

Digital Hybrid Breast PET/MRI for Enhanced Diagnosis of Breast Cancer

Title Authors Journal Link
Crystal Delay and Time Walk Correction Methods for Coincidence Resolving Time Improvements of a Digital-Silicon-Photomultiplier-Based PET/MRI Insert D Schug et al. IEEE Transactions on Radiation and Plasma Medical Sciences Read
Intercrystal Scatter Rejection for Pixelated PET Detectors C Ritzer et al. IEEE Transactions on Radiation and Plasma Medical Sciences Read
Development of a Non-invasive Assessment of Hypoxia and Neovascularization with Magnetic Resonance Imaging in Benign and Malignant Breast Tumors: Initial Results A Stadlbauer et al. Molecular Imaging and Biology Read
Characterization methods for comprehensive evaluations of shielding materials used in an MRI N Gross-Weege et al. Medical Physics Read
Multiparametric MRI model with dynamic contrast-enhanced and diffusion-weighted imaging enables breast cancer diagnosis with high accuracy M Zhang et al. Journal of Magnetic Resonance Imaging Read
Automatic segmentation and classification of breast lesions through identification of informative multiparametric PET/MRI features WD Vogl et al. European Radiology Experimental Read
PIK3CA Mutational Status Is Associated with High Glycolytic Activity in ER+/HER2− Early Invasive Breast Cancer: a Molecular Imaging Study Using [18F]FDG PET/CT H Magometschnigg Molecular Imaging and Biology Read
Sequential [18F]FDG-[18F]FMISO PET and Multiparametric MRI at 3T for Insights into Breast Cancer Heterogeneity and Correlation with Patient Outcomes: First Clinical Experience P Andrzejewski et al. Contrast Media & Molecular Imaging Read
A multiparametric [18F]FDG PET/MRI diagnostic model including imaging biomarkers of the tumor and contralateral healthy breast tissue aids breast cancer diagnosis D Leithner et al. European Journal of Nuclear Medicine and Molecular Imaging Read
Limited role of DWI with apparent diffusion coefficient mapping in breast lesions presenting as non-mass enhancement on dynamic contrast-enhanced MRI D Avendano et al. Breast Cancer Research Read
MR image corrections for PET-induced gradient distortions N Gross-Weege Physics in Medicine & Biology Read
Algorithms for joint activity-attenuation estimation from positron emission tomography scatter Y Berker et al. EJNMMI Physics Read
A High Count-Rate and Depth-of-Interaction Resolving Single-Layered One-Side Readout Pixelated Scintillator Crystal Array for PET Applications JMC Brown et al. IEEE Transactions on Radiation and Plasma Medical Sciences Read
Spiral blurring correction with water-fat separation for magnetic resonance fingerprinting in the breast T Nolte et al. Magnetic Resonance in Medicine Read
Investigation of the Power Consumption of the PETsys TOFPET2 ASIC V Nadig et al. arXiv Read
Automated Detection and Segmentation of Nonmass-Enhancing Breast Tumors with Dynamic Contrast-Enhanced Magnetic Resonance Imaging I Alvarez Illan et al. Contrast Media & Molecular Imaging Read

 

CoSTREAM

A multidisciplinary approach to understand the link between stroke and Alzheimer’s

Title Authors Journal Link
Higher Education Is Associated with a Lower Risk of Dementia after a Stroke or TIA. The Rotterdam Study SS Mirza et al. Neuroepidemiology Read
Mixed brain lesions mediate the association between cardiovascular risk burden and cognitive decline in old age: A population-based study R Wang et al. Alzheimer's & Dementia: The Journal of the Alzheimer's Association Read
High-throughput compound evaluation on 3D networks of neurons and glia in a microfluidic platform NR Wevers et al. Scientific Reports Read
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease R Sims et al. Nature Genetics Read
Cognitive Trajectories of Older Adults With Prediabetes and Diabetes: A Population-Based Cohort Study A Marseglia et al. The Journals of Gerontology: Series A Read
The Nordic Prudent Diet Reduces Risk of Cognitive Decline in the Swedish Older Adults: A Population-Based Cohort Study B Shakersain et al. Nutrients Read
A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy C Tamar Silva et al. BMC Medical Genomics Read
Meta-analysis of genetic association with diagnosed Alzheimer's disease identifies novel risk loci and implicates Abeta, Tau, immunity and lipid processing BW Kunkle et al. bioRxiv Read
Von Willebrand factor and ADAMTS13 activity in relation to risk of dementia: a population-based study FJ Wolters et al. Scientific Reports Read
Effect of the NU-AGE Diet on Cognitive Functioning in Older Adults: A Randomized Controlled Trial A Marseglia et al. Frontiers in Physiology Read
Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia LCA Rutten-Jacobs et al. Stroke Read
COL4A2 is associated with lacunar ischemic stroke and deep ICH: meta-analyses among 21,500 cases and 40,600 controls K Rannikmäe et al. Neurology Read
Blood-based metabolic signatures in Alzheimer's disease FA de Leeuw et al. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring Read
Vascular Cognitive Impairment M Dichgans et al. Circulation Research Read
Trends in the incidence of dementia: design and methods in the Alzheimer Cohorts Consortium LB Chibnik et al. European Journal of Epidemiology Read
Quantitative profiling of endocannabinoids and related N-acylethanolamines in human CSF using nano LC-MS/MS V Kantae et al. Journal of Lipid Research Read
Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts J Tynkkynen et al. Alzheimer's & Dementia Read
Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies SJ van der Lee et al. Alzheimer's & Dementia Read
Planar cell polarity pathway and development of the human visual cortex J Shin et al. bioRxiv Read
A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport NR Wevers et al. Fluids and Barriers of the CNS Read
Subregional volumes of the hippocampus in relation to cognitive function and risk of dementia TE Evans et al. NeuroImage Read
An Active Lifestyle Reinforces the Effect of a Healthy Diet on Cognitive Function: A Population-Based Longitudinal Study N Shakersain et al. Nutrients Read
Genetic Determinants of Cortical Structure (Thickness, Surface Area and Volumes) among Disease Free Adults in the CHARGE Consortium E Hofer et al. bioRxiv Read
MRI load of cerebral microvascular lesions and neurodegeneration, cognitive decline, and dementia R Wang et al. Neurology Read
Cerebrovascular Disease Knowledge Portal KM Crawford et al. Stroke Read
Subjective Sleep Quality is not Associated with Incident Dementia: The Rotterdam Study TS Lysen et al. Journal of Alzheimer's Disease Read
The effect of APOE and other common genetic variants on the onset of Alzheimer's disease and dementia: a community-based cohort study SJ van der Lee et al. The Lancet Neurology Read
Metabolic profiling of intra- and extracranial carotid artery atherosclerosis D Vojinovic et al. Atherosclerosis Read
Does Treating Vascular Risk Factors Prevent Dementia and Alzheimer's Disease? A Systematic Review and Meta-Analysis SC Larsson et al. Journal of Alzheimer's Disease Read
Tooth loss is associated with accelerated cognitive decline and volumetric brain differences: a population-based study CS Dintica et al. Neurobiology of Aging Read
Disentangling the biological pathways involved in early features of Alzheimer's disease in the Rotterdam Study S Ahmad et al. Alzheimer's & Dementia Read
Prediabetes and diabetes accelerate cognitive decline and predict microvascular lesions: A population-based cohort study A Marseglia et al. Alzheimer's & Dementia Read
Serum neurofilament light S Tiedt et al. Neurology Read
Tau PET imaging evidence in patients with cognitive impairment: preparing for clinical use C Noirot et al. Clinical and Translational Imaging Read
Life expectancy with and without dementia: a population-based study of dementia burden and preventive potential FJ Wolters et al. American Journal of Epidemiology Read
Helicobacter pylori and the risk of dementia: A population-based study L Fani et al. Alzheimer's & Dementia Read
Clinical Significance of Magnetic Resonance Imaging Markers of Vascular Brain Injury S Debette et al. JAMA Neurology Read
Role of Non-Coding RNAs in Stroke S Tiedt et al. Stroke Read
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes R Malik et al. Nature Genetics Read
Challenges and opportunities in stroke genetics R Malik et al. Cardiovascular Research Read
THE IMPACT OF NUTRIENT PATTERNS ON COGNITIVE DECLINE AMONG SWEDISH OLDER ADULTS: A POPULATION-BASED LONGITUDINAL STUDY F Prinelli et al. Alzheimer's & Dementia Read
IMPAIRED OLFACTORY FUNCTION IS ASSOCIATED WITH ACCELERATED COGNITIVE DECLINE AND NEURODEGENERATION IN THE BRAIN CS Dintica et al. Alzheimer's & Dementia Read
Modifiable pathways in Alzheimer's disease: Mendelian randomisation analysis SC Larsson et al. BMJ Read
Association of Lifespan Cognitive Reserve Indicator With Dementia Risk in the Presence of Brain Pathologies H Xu et al. JAMA Neurology Read
High dilated perivascular space burden: a new MRI marker for risk of intracerebral hemorrhage MG Duperron et al. Neurobiology of Aging Read
Genetically Determined Levels of Circulating Cytokines and Risk of Stroke MK Georgakis et al. Circulation Read
Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype Y Ma et al. JAMA Neurology Read
Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes MK Georgakis et al. Circulation: Genomic and Precision Medicine Read
The A/T/N model applied through imaging biomarkers in a memory clinic A Dodich et al. European Journal of Nuclear Medicine and Molecular Imaging Read
Vascular Cognitive Impairment and Dementia C Iadecola et al. Journal of the American College of Cardiology Read
Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke G Abraham et al. Nature Communications Read
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis J Liu et al. Nature Communications Read
Circulating Monocyte Chemoattractant Protein-1 and Risk of Stroke MK Georgakis et al. Circulation Research Read
Psychosocial working conditions, trajectories of disability, and the mediating role of cognitive decline and chronic diseases: A population-based cohort study KY Pan et al. PLOS Medicine Read
The impact of nutrient-based dietary patterns on cognitive decline in older adults F Prinelli et al. Clinical Nutrition Read
Working Life Psychosocial Conditions in Relation to Late-Life Cognitive Decline: A Population-Based Cohort Study KY Pan et al. Journal of Alzheimer's Disease Read
Novel technologies for metabolomics: More for less P Miggiels et al. TrAC Trends in Analytical Chemistry Read
The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1 M Prestel et al. Stroke Read
Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting G Chauhan et al. Neurology Read
Leisure activity and social integration mitigate the risk of dementia related to cardiometabolic diseases: A population‐based longitudinal study Z Wang et al. Alzheimer's & Dementia Read
WMH and long-term outcomes in ischemic stroke MK Georgakis et al. Neurology Read
Global Brain Perfusion and the Risk of Transient Ischemic Attack and Ischemic Stroke: The Rotterdam Study L Fani et al. Journal of the American Heart Association Read
Prognostic relevance of cortical superficial siderosis in cerebral amyloid angiopathy FA Wollenweber et al. Neurology Read
The role of haematological traits in risk of ischaemic stroke and its subtypes EL Harshfield et al. Brain Read
Natural history of prediabetes in older adults from a population‐based longitudinal study Y Shang et al. Journal of Internal Medicine Read
Specific nutrient patterns are associated with higher structural brain integrity in dementia-free older adults F Prinelli et al. NeuroImage Read
A prospective study of serum metabolites and risk of ischemic stroke D Sun et al. Neurology Read
Telomere Length and the Risk of Alzheimer's Disease: The Rotterdam Study L Fani et al. Journal of Alzheimer's Disease Read
Type 2 diabetes in midlife and risk of cerebrovascular disease in late life: a prospective nested case−control study in a nationwide Swedish twin cohort R Yang et al. Diabetologia Read
Balance between innate versus adaptive immune system and the risk of dementia: a population-based cohort study KD van der Willik et al. Journal of Neuroinflammation Read
Genetic risk of dementia mitigated by cognitive reserve: A cohort study S Dekhtyar et al. Annals of Neurology Read
Homocysteine and small vessel stroke: A mendelian randomization analysis SC Larsson et al. Annals of Neurology Read
Vitamin D Status and Risk of Stroke BP Berghout et al. Stroke Read
Association of variants in HTRA1 and NOTCH3 with MRI-defined extremes of cerebral small vessel disease in older subjects A Mishra et al. Brain Read
Participating in Mental, Social, and Physical Leisure Activities and Having a Rich Social Network Reduce the Incidence of Diabetes-Related Dementia in a Cohort of Swedish Older Adults A Marseglia et al. Diabetes Care Read
Influence of Genetic Variation in PDE3A on Endothelial Function and Stroke M Traylor et al. Hypertension Read
Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine GLJ Onderwater et al. Neurology Read