The Horizon 2020 project CoSTREAM aims to improve our understanding of the co-occurrence of stroke and Alzheimer’s disease. The consortium builds upon an extensive infrastructure of longitudinal follow-up studies spanning up to 25 years. These studies have data on both diseases as separate clinical outcomes, and contain information on a broad range of aetiological factors ranging from genetics and metabolomics to brain structure and function.

An essential concept of the CoSTREAM project is that stroke and Alzheimer’s disease are sequential diseases with overlapping pathophysiological mechanisms and shared risk factors. The project will particularly focus on these common mechanisms and disentangle when and how these mechanisms diverge to cause either stroke, or Alzheimer’s disease, or both.

CoSTREAM’s highly multidisciplinary consortium consists of 11 institutions from seven countries. It includes epidemiologists, geneticists, radiologists and neurologists with a longstanding track-record in researching stroke and Alzheimer’s disease. EIBIR leads the project management and dissemination activities of the project.